Written by Mark Williams - March 02, 2023
Estradot is a hormone replacement therapy (HRT) containing estradiol, the primary female hormone. The therapy is used to treat various symptoms of menopause and reduce its severity in some women. It is one of many forms of HRT available in the market, with other types being progesterone and testosterone HRTs. As per conventional medicine, it is believed that estradiol relieves the symptoms of menopause associated with low hormone levels in postmenopausal women.
However, there have been debates about whether Estradot falls under the category of bioidentical hormones or not. A bioidentical hormone is identical to natural hormones in terms of molecular structure as well as exact physiologic effects on the body; hence it is believed to be more effective than synthetic hormones like progestins and conjugated estrogens.
Therefore, the question arises - Is Estradot a bioidentical hormone?
The answer depends on different factors and depends on individual cases. While Estradot does contain estradiol, which can be considered a bioidentical hormone, different preparations may contain varying concentrations and formulations – for example transdermal patches may have higher concentrations than oral formulations due to absorption limitations in the GI tract. And since all bioidenticals are not identical even among themselves – molecularly speaking – one particular formulation cannot be labeled as ‘bioidentical’ at best it can only be assumed that it has less side effects when compared to synthetic therapies like conjugated equine estrogen or medroxyprogesterone acetate (MPA).
In addition to this, there are other considerations which must also be taken into account while deciding if Estradot qualifies as a bioidentical hormone:
The method by which they are formulated: Most synthetic hormones are made using chemical reactions whereas bio-hormones are derived through enzymatic processes or fermentation techniques resulting in hormones that closely resemble those found naturally in human bodies.
The type of delivery system utilized for administering these hormones: Most synthetic hormones come with injection methods whereas many natural therapies utilize topical creams, gels, drops and nasal sprays to dispense smaller doses over time providing better control over dosage amounts.
Overall, given these considerations along with patient characteristics such as age and health history it can become quite difficult to determine conclusively if any particular product qualifies as being truly “bio-identical” but based on current evidence we can infer that Estradot contains biologically active form(s) of estrogen making it closer to being classified as “natural” compared to chemically produced alternatives.
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